{"id":5045,"date":"2026-10-22T16:17:04","date_gmt":"2026-10-22T07:17:04","guid":{"rendered":"https:\/\/bdsl.jbnu.ac.kr\/blog\/?p=5045"},"modified":"2026-10-22T16:46:59","modified_gmt":"2026-10-22T07:46:59","slug":"assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease","status":"publish","type":"post","link":"https:\/\/bdsl.jbnu.ac.kr\/blog\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\/","title":{"rendered":"[Journal Club] Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naive and Treated Crohn&#8217;s Disease"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"> Inflammatory Bowel Diseases 2022<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Suresh Venkateswaran, Peng Qiu and Subra Kugathasan<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Summary<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\uc5f0\uad6c \ud544\uc694\uc131<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Crohn&#8217;s disease shows considerable heterogeneity in disease progression and treatment response. Bulk transcriptomic studies cannot resolve cell type-specific changes, necessitating single-cell approaches to better understand disease mechanisms.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\uc5f0\uad6c \ubaa9\uc801<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">To characterize cellular composition and transcriptional changes in the ileal mucosa of treatment-na\u00efve and treated Crohn&#8217;s disease patients using single-cell RNA sequencing<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\uc2e4\ud5d8 \ubc29\ubc95<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Terminal Ileal biopsies from 27 subjects (from controls, treatment-na\u00efve CD patients, and established CD) were analyzed using 10x Genomics single-cell RNA sequencing. Analyzed for cell proportions and differential gene expression analysis, and  GO enrichment analysis were performed<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\uc8fc\uc694 \uacb0\uacfc<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Treatment-na\u00efve Crohn&#8217;s disease exhibited substantial epithelial remodeling characterized by alterations in enterocytes, goblet cells, tuft cells, BEST4+ cells, and M cells.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Immune-cell abundance showed relatively minor changes. <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both epithelial and immune compartments displayed significant transcriptional reprogramming, particularly involving antigen-presentation and inflammatory pathways. <\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Remission and refractory patients were distinguished primarily by transcriptional differences rather than cellular composition.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Take home message<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The study suggests that Crohn&#8217;s disease is driven more by changes in cellular function and transcriptional activity than by large shifts in cell abundance<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Points helpful for my research<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This study supports the use of scRNA-seq for patient stratification and highlights the importance of integrating cellular composition with transcriptional states. The findings are particularly relevant for identifying immune and epithelial signatures associated with disease activity, remission, and treatment resistance.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">PDF files<\/h3>\n\n\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/doi.org\/10.1093\/ibd\/izac201\">https:\/\/doi.org\/10.1093\/ibd\/izac201<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inflammatory Bowel Diseases 2022 Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Suresh Venkateswaran, Peng Qiu and Subra Kugathasan Summary \uc5f0\uad6c \ud544\uc694\uc131 Crohn&#8217;s disease shows considerable heterogeneity in disease progression and treatment response. Bulk transcriptomic studies cannot resolve cell type-specific changes, necessitating single-cell approaches to better understand disease mechanisms. \uc5f0\uad6c \ubaa9\uc801 To characterize cellular composition and transcriptional [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_uag_custom_page_level_css":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5045","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>[Journal Club] Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naive and Treated Crohn&#039;s Disease - Biomedical Data Science Laboratory<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bdsl.jbnu.ac.kr\/blog\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"[Journal Club] Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naive and Treated Crohn&#039;s Disease - Biomedical Data Science Laboratory\" \/>\n<meta property=\"og:description\" content=\"Inflammatory Bowel Diseases 2022 Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Suresh Venkateswaran, Peng Qiu and Subra Kugathasan Summary \uc5f0\uad6c \ud544\uc694\uc131 Crohn&#8217;s disease shows considerable heterogeneity in disease progression and treatment response. Bulk transcriptomic studies cannot resolve cell type-specific changes, necessitating single-cell approaches to better understand disease mechanisms. \uc5f0\uad6c \ubaa9\uc801 To characterize cellular composition and transcriptional [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/bdsl.jbnu.ac.kr\/blog\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Biomedical Data Science Laboratory\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-22T07:17:04+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-22T07:46:59+00:00\" \/>\n<meta name=\"author\" content=\"Maimuna Lwanga\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Maimuna Lwanga\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\\\/\"},\"author\":{\"name\":\"Maimuna Lwanga\",\"@id\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/#\\\/schema\\\/person\\\/d61d2ea059aa9317fb2f47d8f2309548\"},\"headline\":\"[Journal Club] Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naive and Treated Crohn&#8217;s Disease\",\"datePublished\":\"2026-10-22T07:17:04+00:00\",\"dateModified\":\"2026-10-22T07:46:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\\\/\"},\"wordCount\":261,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\\\/\",\"url\":\"https:\\\/\\\/bdsl.jbnu.ac.kr\\\/blog\\\/assessing-cellular-and-transcriptional-diversity-of-ileal-mucosa-among-treatment-naive-and-treated-crohns-disease\\\/\",\"name\":\"[Journal Club] Assessing Cellular and Transcriptional Diversity of Ileal Mucosa Among Treatment-Naive and Treated Crohn's Disease - 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Kolachala, Suresh Venkateswaran, Peng Qiu and Subra Kugathasan Summary \uc5f0\uad6c \ud544\uc694\uc131 Crohn&#8217;s disease shows considerable heterogeneity in disease progression and treatment response. 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