"Molecule ChEMBL ID"	"Molecule Name"	"Molecule Max Phase"	"Molecular Weight"	"#RO5 Violations"	"AlogP"	"Compound Key"	"Smiles"	"Standard Type"	"Standard Relation"	"Standard Value"	"Standard Units"	"pChEMBL Value"	"Data Validity Comment"	"Comment"	"Uo Units"	"Ligand Efficiency BEI"	"Ligand Efficiency LE"	"Ligand Efficiency LLE"	"Ligand Efficiency SEI"	"Potential Duplicate"	"Assay ChEMBL ID"	"Assay Description"	"Assay Type"	"BAO Format ID"	"BAO Label"	"Assay Organism"	"Assay Tissue ChEMBL ID"	"Assay Tissue Name"	"Assay Cell Type"	"Assay Subcellular Fraction"	"Assay Parameters"	"Assay Variant Accession"	"Assay Variant Mutation"	"Target ChEMBL ID"	"Target Name"	"Target Organism"	"Target Type"	"Document ChEMBL ID"	"Source ID"	"Source Description"	"Document Journal"	"Document Year"	"Cell ChEMBL ID"	"Properties"
"CHEMBL1908391"	"MASITINIB"	"3"	"498.66"	"1"	"5.26"	"AB-1010"	"Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL101253"	"VATALANIB"	"3"	"346.82"	"1"	"5.01"	"PTK-787"	"Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL379218"	""	"0"	"358.45"	"0"	"3.88"	"A-674563"	"Cc1n[nH]c2ccc(-c3cncc(OC[C@@H](N)Cc4ccccc4)c3)cc12"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL230011"	"TG100-115"	"2"	"346.35"	"0"	"2.33"	"TG-100-115"	"Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1614701"	"SELUMETINIB"	"4"	"457.69"	"0"	"3.53"	"AZD6244"	"Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL483321"	"CP-724714"	"2"	"469.55"	"0"	"4.95"	"CP-724714"	"COCC(=O)NC/C=C/c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL553"	"ERLOTINIB"	"4"	"393.44"	"0"	"3.41"	"Erlotinib"	"C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL572881"	"MOTESANIB"	"3"	"373.46"	"0"	"4.04"	"AMG-706"	"CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL103667"	"DORAMAPIMOD"	"2"	"527.67"	"2"	"5.99"	"BIRB-796"	"Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL296468"	"BMS-387032"	"1"	"380.54"	"0"	"3.66"	"BMS-387032/SNS-032"	"CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL558752"	"RAF-265"	"2"	"518.42"	"2"	"6.93"	"CHIR-265/RAF-265"	"Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL428690"	"ALVOCIDIB"	"3"	"401.85"	"0"	"3.30"	"Flavopiridol"	"CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1"	"Kd"	"'='"	"3300.0"	"nM"	"5.48"	""	""	"UO_0000065"	"13.64"	"0.27"	"2.18"	"5.82"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL261849"	"GW632580X"	"0"	"366.42"	"0"	"2.83"	"GW-2580"	"COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL428690"	"ALVOCIDIB"	"3"	"401.85"	"0"	"3.30"	"Flavopiridol"	"CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1"	"Kd"	"'='"	"3300.0"	"nM"	"5.48"	""	""	"UO_0000065"	"13.64"	"0.27"	"2.18"	"5.82"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL572881"	"MOTESANIB"	"3"	"373.46"	"0"	"4.04"	"Motesanib"	"CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21"	"Kd"	"'='"	"1.0"	"nM"	"9.00"	""	"Uncertain"	"UO_0000065"	"24.10"	"0.44"	"4.96"	"11.40"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 1.0 None"
"CHEMBL2035187"	"PACRITINIB"	"3"	"472.59"	"0"	"4.96"	"Pacritinib"	"C1=C/COCc2cc(ccc2OCCN2CCCC2)Nc2nccc(n2)-c2cccc(c2)COC/1"	"Kd"	"'='"	"160.0"	"nM"	"6.80"	""	"Uncertain"	"UO_0000065"	"14.38"	"0.27"	"1.84"	"9.89"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.72 None"
"CHEMBL3991933"	""	"0"	"308.35"	"0"	"3.11"	"Sapanisertib"	"Cc1nc2cc(-c3nn(C(C)C)c4ncnc(N)c34)ccc2o1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3699142"	""	"0"	"464.57"	"0"	"4.17"	"BI-847325"	"CCNC(=O)C#Cc1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(CN(C)C)cc1)c1ccccc1"	"Kd"	"'='"	"875.0"	"nM"	"6.06"	""	"Active"	"UO_0000065"	"13.04"	"0.24"	"1.89"	"8.25"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.71 None"
"CHEMBL288441"	"BOSUTINIB"	"4"	"530.46"	"2"	"5.19"	"Bosutinib"	"COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl"	"Kd"	"'='"	"820.0"	"nM"	"6.09"	""	"Active"	"UO_0000065"	"11.47"	"0.23"	"0.90"	"7.34"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.89 None"
"CHEMBL2103839"	"RIDAFOROLIMUS"	"3"	"990.22"	"3"	"7.74"	"Deforolimus"	"CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OP(C)(C)=O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1230609"	"FORETINIB"	"2"	"632.66"	"2"	"5.77"	"Foretinib"	"COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3109738"	""	"0"	"457.37"	"1"	"5.14"	"JNJ-26483327"	"COc1cc2ncnc3c2cc1OCCCCCN(C)Cc1ccc(Br)cc1N3"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL554"	"LAPATINIB"	"4"	"581.07"	"2"	"6.14"	"Lapatinib"	"CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1922094"	"APITOLISIB"	"2"	"498.61"	"1"	"0.90"	"Apitolisib"	"Cc1c(CN2CCN(C(=O)[C@H](C)O)CC2)sc2c(N3CCOCC3)nc(-c3cnc(N)nc3)nc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545110"	"RIBOCICLIB"	"4"	"434.55"	"0"	"2.80"	"Ribociclib"	"CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1234354"	"PF-04691502"	"2"	"425.49"	"0"	"2.25"	"PF-04691502"	"COc1ccc(-c2cc3c(C)nc(N)nc3n([C@H]3CC[C@H](OCCO)CC3)c2=O)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545307"	"MERESTINIB"	"2"	"552.54"	"2"	"5.75"	"LY-2801653"	"Cc1ccc(C(=O)Nc2ccc(Oc3cc4cnn(C)c4cc3-c3cn[nH]c3)c(F)c2)c(=O)n1-c1ccc(F)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3544964"	"RAVOXERTINIB"	"1"	"440.87"	"0"	"3.16"	"GDC-0994"	"Cn1nccc1Nc1nccc(-c2ccn([C@H](CO)c3ccc(Cl)c(F)c3)c(=O)c2)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1950289"	"TANZISERTIB"	"2"	"448.45"	"0"	"3.66"	"Tanzisertib"	"O[C@H]1CC[C@H](Nc2ncc3nc(Nc4c(F)cc(F)cc4F)n([C@H]4CCOC4)c3n2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1908397"	"KW-2449"	"1"	"332.41"	"0"	"2.78"	"KW-2449"	"O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1"	"Kd"	"'='"	"1428.0"	"nM"	"5.84"	""	"Active"	"UO_0000065"	"17.58"	"0.32"	"3.07"	"9.58"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.92 None"
"CHEMBL1090090"	"VX-702"	"2"	"404.32"	"0"	"3.62"	"VX-702"	"NC(=O)c1ccc(N(C(N)=O)c2c(F)cccc2F)nc1-c1ccc(F)cc1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL564829"	"MILCICLIB"	"2"	"460.59"	"0"	"2.57"	"Milciclib"	"CNC(=O)c1nn(C)c2c1C(C)(C)Cc1cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc1-2"	"Kd"	"'='"	"212.0"	"nM"	"6.67"	""	"Active"	"UO_0000065"	"14.49"	"0.27"	"4.10"	"7.32"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.95 None"
"CHEMBL1173655"	"AFATINIB"	"4"	"485.95"	"0"	"4.39"	"BIBW-2992"	"CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL509032"	"TAE-684"	"0"	"614.22"	"2"	"5.02"	"TAE-684"	"COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1"	"Kd"	"'='"	"140.0"	"nM"	"6.85"	""	""	"UO_0000065"	"11.16"	"0.22"	"1.83"	"6.66"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL91829"	"RUBOXISTAURIN"	"3"	"468.56"	"0"	"3.51"	"LY-333531"	"CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1"	"Kd"	"'='"	"2600.0"	"nM"	"5.58"	""	""	"UO_0000065"	"11.92"	"0.22"	"2.08"	"8.15"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL124660"	"TANDUTINIB"	"2"	"562.72"	"2"	"5.03"	"MLN-518"	"COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL941"	"IMATINIB"	"4"	"493.62"	"0"	"4.59"	"Imatinib"	"Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL572878"	"TOZASERTIB"	"2"	"464.60"	"0"	"3.50"	"VX-680/MK-0457"	"Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1"	"Kd"	"'='"	"72.0"	"nM"	"7.14"	""	""	"UO_0000065"	"15.37"	"0.30"	"3.64"	"7.00"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL525191"	""	"0"	"334.38"	"0"	"2.73"	"GDC-0879"	"OCCn1cc(-c2ccc3c(c2)CC/C3=N\O)c(-c2ccncc2)n1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL535"	"SUNITINIB"	"4"	"398.48"	"0"	"3.33"	"Sunitinib"	"CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C"	"Kd"	"'='"	"16.0"	"nM"	"7.80"	""	""	"UO_0000065"	"19.56"	"0.37"	"4.47"	"10.09"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL477772"	"PAZOPANIB"	"4"	"437.53"	"0"	"3.14"	"GW-786034"	"Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O"	"Kd"	"'='"	"750.0"	"nM"	"6.12"	""	""	"UO_0000065"	"14.00"	"0.27"	"2.98"	"5.15"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL522892"	"DOVITINIB"	"3"	"392.44"	"0"	"2.54"	"CHIR-258/TKI-258"	"CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1"	"Kd"	"'='"	"44.0"	"nM"	"7.36"	""	""	"UO_0000065"	"18.75"	"0.35"	"4.82"	"7.82"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL477772"	"PAZOPANIB"	"4"	"437.53"	"0"	"3.14"	"Pazopanib"	"Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O"	"Kd"	"'='"	"750.0"	"nM"	"6.12"	""	""	"UO_0000065"	"14.00"	"0.27"	"2.98"	"5.15"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1289926"	"AXITINIB"	"4"	"386.48"	"0"	"4.64"	"AG-013736"	"CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1"	"Kd"	"'='"	"330.0"	"nM"	"6.48"	""	""	"UO_0000065"	"16.77"	"0.32"	"1.84"	"9.17"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL574737"	"UCN-01"	"2"	"482.54"	"0"	"3.84"	"UCN-01"	"CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2105717"	"CABOZANTINIB"	"4"	"501.51"	"2"	"5.54"	"Cabozantinib"	"COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545366"	"VOXTALISIB"	"2"	"270.30"	"0"	"1.09"	"XL-765"	"CCn1c(=O)c(-c2cc[nH]n2)cc2c(C)nc(N)nc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1201182"	"TEMSIROLIMUS"	"4"	"1030.30"	"None"	"None"	"Torisel"	"CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL571546"	"TIRBANIBULIN"	"4"	"431.54"	"0"	"3.32"	"KX2-391"	"O=C(Cc1ccc(-c2ccc(OCCN3CCOCC3)cc2)cn1)NCc1ccccc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2133806"	"JNJ-38877605"	"1"	"377.36"	"0"	"3.21"	"JNJ-38877605"	"Cn1cc(-c2ccc3nnc(C(F)(F)c4ccc5ncccc5c4)n3n2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3426621"	"RIPASUDIL"	"2"	"323.39"	"0"	"1.75"	"Ripasudil"	"C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3120215"	"OSI-027"	"2"	"406.45"	"0"	"3.22"	"OSI-027"	"COc1cccc2cc(-c3nc([C@H]4CC[C@H](C(=O)O)CC4)n4ncnc(N)c34)[nH]c12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3907479"	"FGFR INHIBITOR DEBIO 1347"	"2"	"356.39"	"0"	"3.35"	"CH-5183284"	"Cc1nc2ccc(-n3ncc(C(=O)c4cc5ccccc5[nH]4)c3N)cc2[nH]1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1952329"	"SGI-1776"	"1"	"405.42"	"0"	"4.05"	"SGI-1776"	"CN1CCC(CNc2ccc3ncc(-c4cccc(OC(F)(F)F)c4)n3n2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3688339"	""	"0"	"487.43"	"1"	"6.04"	"OTS-167"	"CC(=O)c1cnc2ccc(-c3cc(Cl)c(O)c(Cl)c3)nc2c1N[C@H]1CC[C@H](CN(C)C)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL475251"	"R-406"	"2"	"470.46"	"0"	"3.63"	"R-406"	"COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL607707"	"PELITINIB"	"2"	"467.93"	"1"	"5.10"	"Pelitinib"	"CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C"	"Kd"	"'='"	"1096.0"	"nM"	"5.96"	""	"Active"	"UO_0000065"	"12.74"	"0.25"	"0.86"	"6.60"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.69 None"
"CHEMBL1241855"	"RIGOSERTIB"	"3"	"451.50"	"0"	"2.80"	"Rigosertib"	"COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(NCC(=O)O)c2)c(OC)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1078178"	"MOMELOTINIB"	"3"	"414.47"	"0"	"2.98"	"Momelotinib"	"N#CCNC(=O)c1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL377300"	"BRIVANIB"	"3"	"370.38"	"0"	"3.52"	"Brivanib"	"Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1289601"	"LENVATINIB"	"4"	"426.86"	"0"	"4.07"	"Lenvatinib"	"COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3301610"	"ABEMACICLIB"	"4"	"506.61"	"1"	"4.94"	"Abemaciclib"	"CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL941"	"IMATINIB"	"4"	"493.62"	"0"	"4.59"	"Imatinib"	"Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL551064"	"AEW-541"	"1"	"425.54"	"0"	"4.67"	"AEW-541"	"Nc1ncnc2c1c(-c1cccc(OCc3ccccc3)c1)cn2[C@H]1C[C@H](N2CCC2)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2105759"	"BARICITINIB"	"4"	"371.43"	"0"	"1.10"	"Baricitinib"	"CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3408248"	""	"0"	"457.48"	"0"	"3.78"	"AZD-8186"	"C[C@@H](Nc1cc(F)cc(F)c1)c1cc(C(=O)N(C)C)cc2c(=O)cc(N3CCOCC3)oc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1614707"	"MUBRITINIB"	"1"	"468.48"	"1"	"6.06"	"Mubritinib"	"FC(F)(F)c1ccc(/C=C/c2nc(COc3ccc(CCCCn4ccnn4)cc3)co2)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1088752"	"LOSMAPIMOD"	"3"	"383.47"	"0"	"3.86"	"Losmapimod"	"Cc1c(F)cc(C(=O)NC2CC2)cc1-c1ccc(C(=O)NCC(C)(C)C)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2028663"	"DABRAFENIB"	"4"	"519.57"	"2"	"5.36"	"Dabrafenib"	"CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2103875"	"TRAMETINIB"	"4"	"615.40"	"1"	"3.94"	"Trametinib"	"CC(=O)Nc1cccc(-n2c(=O)n(C3CC3)c(=O)c3c(Nc4ccc(I)cc4F)n(C)c(=O)c(C)c32)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1090479"	"GSK-1070916"	"1"	"507.64"	"2"	"5.94"	"GSK-1070916"	"CCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2323775"	"MK-8033"	"1"	"471.54"	"0"	"3.16"	"MK-8033"	"Cn1cc(-c2cnc3ccc4ccc(CS(=O)(=O)NCc5ccccn5)cc4c(=O)c3c2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3402762"	"TEPOTINIB"	"4"	"492.58"	"0"	"4.01"	"Tepotinib"	"CN1CCC(COc2cnc(-c3cccc(Cn4nc(-c5cccc(C#N)c5)ccc4=O)c3)nc2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1079175"	"MK-2206"	"2"	"407.48"	"0"	"4.24"	"MK-2206"	"NC1(c2ccc(-c3nc4ccn5c(=O)[nH]nc5c4cc3-c3ccccc3)cc2)CCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL4465866"	""	"0"	"901.82"	"None"	"None"	"8a"	"CO[C@@H]1[C@H](NCCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"17.0"	"nM"	"7.77"	""	""	"UO_0000065"	"8.62"	"None"	"None"	"None"	"False"	"CHEMBL4322789"	"Binding affinity to recombinant N-terminal His-FLAG-GST-tagged MAP4K1 (unknown origin) (1 to 346 residues) expressed in baculovirus infected Sf9 insect cells incubated for 1 hr by TR-FRET assay"	"B"	"BAO_0000219"	"cell-based format"	"Homo sapiens"	"None"	"None"	"Sf9"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL4321812"	"1"	"Scientific Literature"	"Bioorg Med Chem Lett"	"2019"	"CHEMBL3308860"	""
"CHEMBL535"	"SUNITINIB"	"4"	"398.48"	"0"	"3.33"	"Sunitinib"	"CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C"	"Kd"	"'='"	"16.0"	"nM"	"7.80"	""	""	"UO_0000065"	"19.56"	"0.37"	"4.47"	"10.09"	"True"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL576982"	"QUIZARTINIB"	"3"	"560.68"	"2"	"5.86"	"AC220"	"CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL608533"	"MIDOSTAURIN"	"4"	"570.65"	"2"	"5.91"	"PKC-412"	"CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"2100.0"	"nM"	"5.68"	""	""	"UO_0000065"	"9.95"	"0.18"	"-0.23"	"7.30"	"True"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL573339"	"PI-103"	"0"	"348.36"	"0"	"2.98"	"PI-103"	"Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL91829"	"RUBOXISTAURIN"	"3"	"468.56"	"0"	"3.51"	"LY-333531"	"CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1"	"Kd"	"'='"	"2600.0"	"nM"	"5.58"	""	""	"UO_0000065"	"11.92"	"0.22"	"2.08"	"8.15"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL10"	"SB-203580"	"0"	"377.44"	"0"	"4.68"	"SB-203580"	"C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL24828"	"VANDETANIB"	"4"	"475.36"	"1"	"5.00"	"ZD-6474"	"COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL223360"	"LINIFANIB"	"3"	"375.41"	"0"	"4.90"	"ABT-869"	"Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1"	"Kd"	"'='"	"830.0"	"nM"	"6.08"	""	""	"UO_0000065"	"16.20"	"0.30"	"1.18"	"6.35"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL522892"	"DOVITINIB"	"3"	"392.44"	"0"	"2.54"	"CHIR-258/TKI-258"	"CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1"	"Kd"	"'='"	"44.0"	"nM"	"7.36"	""	""	"UO_0000065"	"18.75"	"0.35"	"4.82"	"7.82"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL1421"	"DASATINIB"	"4"	"488.02"	"0"	"3.31"	"Dasatinib"	"Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1"	"Kd"	"'='"	"980.0"	"nM"	"6.01"	""	""	"UO_0000065"	"12.31"	"0.25"	"2.70"	"5.64"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL259084"	"MLN-8054"	"1"	"476.87"	"1"	"5.87"	"MLN-8054"	"O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL440084"	"SB-431542"	"0"	"384.40"	"0"	"3.63"	"SB-431542"	"NC(=O)c1ccc(-c2nc(-c3ccccn3)c(-c3ccc4c(c3)OCO4)[nH]2)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL215152"	"AZD-1152-HQPA"	"0"	"507.57"	"1"	"3.50"	"AZD-1152 HQPA"	"CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL607707"	"PELITINIB"	"2"	"467.93"	"1"	"5.10"	"EKB-569"	"CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C"	"Kd"	"'='"	"270.0"	"nM"	"6.57"	""	""	"UO_0000065"	"14.04"	"0.27"	"1.47"	"7.28"	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL261849"	"GW632580X"	"0"	"366.42"	"0"	"2.83"	"GW-2580"	"COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL2216870"	"IDELALISIB"	"4"	"415.43"	"0"	"3.75"	"Idelalisib"	"CC[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(F)c2c(=O)n1-c1ccccc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL488436"	"AZD-5438"	"1"	"371.47"	"0"	"3.38"	"AZD-5438"	"Cc1ncc(-c2ccnc(Nc3ccc(S(C)(=O)=O)cc3)n2)n1C(C)C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2219422"	"AFURESERTIB"	"2"	"427.33"	"0"	"3.89"	"GSK-2110183"	"Cn1ncc(Cl)c1-c1cc(C(=O)N[C@H](CN)Cc2cccc(F)c2)sc1Cl"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3590106"	"ULIXERTINIB"	"2"	"433.34"	"0"	"4.67"	"Ulixertinib"	"CC(C)Nc1cc(-c2c[nH]c(C(=O)N[C@H](CO)c3cccc(Cl)c3)c2)c(Cl)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1231124"	"AZD-1480"	"2"	"348.77"	"0"	"3.01"	"AZD-1480"	"Cc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)[nH]n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1789941"	"RUXOLITINIB"	"4"	"306.37"	"0"	"3.47"	"Ruxolitinib"	"N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL428690"	"ALVOCIDIB"	"3"	"401.85"	"0"	"3.30"	"Alvocidib"	"CN1CC[C@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@H](O)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL939"	"GEFITINIB"	"4"	"446.91"	"0"	"4.28"	"Gefitinib"	"COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL495727"	"AT-9283"	"2"	"381.44"	"0"	"2.07"	"AT-9283"	"O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1"	"Kd"	"'='"	"214.0"	"nM"	"6.67"	""	"Active"	"UO_0000065"	"17.49"	"0.33"	"4.60"	"6.01"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.88 None"
"CHEMBL3182444"	"MK-5108"	"1"	"461.95"	"1"	"5.71"	"MK-5108"	"O=C(O)C1(Cc2cccc(Nc3nccs3)n2)CCC(Oc2cccc(Cl)c2F)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL572878"	"TOZASERTIB"	"2"	"464.60"	"0"	"3.50"	"VX-680/MK-0457"	"Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1"	"Kd"	"'='"	"72.0"	"nM"	"7.14"	""	""	"UO_0000065"	"15.37"	"0.30"	"3.64"	"7.00"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL603469"	"LESTAURTINIB"	"3"	"439.47"	"0"	"3.47"	"CEP-701"	"C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O"	"Kd"	"'='"	"38.0"	"nM"	"7.42"	""	""	"UO_0000065"	"16.88"	"0.31"	"3.95"	"8.37"	"True"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL521851"	"PICTILISIB"	"2"	"513.65"	"1"	"2.15"	"GDC0941"	"CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL513909"	"BI-2536"	"2"	"521.67"	"1"	"3.56"	"BI-2536"	"CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3991935"	""	"0"	"438.31"	"0"	"3.30"	"P-276-00"	"CN1CC[C@@H](c2c(O)cc(O)c3c(=O)cc(-c4ccccc4Cl)oc23)[C@@H]1CO.Cl"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1879463"	"DACTOLISIB"	"3"	"469.55"	"1"	"5.89"	"NVP-BEZ235"	"Cn1c(=O)n(-c2ccc(C(C)(C)C#N)cc2)c2c3cc(-c4cnc5ccccc5c4)ccc3ncc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2146883"	"COBIMETINIB"	"4"	"531.32"	"1"	"3.78"	"Cobimetinib"	"O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2103882"	"TIVANTINIB"	"3"	"369.42"	"0"	"3.59"	"Tivantinib"	"O=C1NC(=O)[C@@H](c2cn3c4c(cccc24)CCC3)[C@@H]1c1c[nH]c2ccccc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2165191"	"AZD-6482"	"1"	"408.46"	"0"	"2.71"	"AZD-6482"	"Cc1cc([C@@H](C)Nc2ccccc2C(=O)O)c2nc(N3CCOCC3)cc(=O)n2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL180022"	"NERATINIB"	"4"	"557.05"	"2"	"5.93"	"Neratinib"	"CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545157"	"TIDEGLUSIB"	"2"	"334.40"	"0"	"3.26"	"Tideglusib"	"O=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3128043"	"PF-03758309"	"1"	"490.64"	"0"	"4.53"	"PF-3758309"	"Cc1nc(Nc2[nH]nc3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1"	"Kd"	"'='"	"2300.0"	"nM"	"5.64"	""	"Active"	"UO_0000065"	"11.49"	"0.22"	"1.11"	"5.52"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.96 None"
"CHEMBL3218575"	"PILARALISIB"	"0"	"448.53"	"0"	"4.49"	"Pilaralisib-analogue"	"Cc1ccc(S(=O)(=O)Nc2nc3ccccc3nc2Nc2ccc3nsnc3c2)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL217092"	"SARACATINIB"	"3"	"542.04"	"1"	"3.94"	"Saracatinib"	"CN1CCN(CCOc2cc(OC3CCOCC3)c3c(Nc4c(Cl)ccc5c4OCO5)ncnc3c2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1171837"	"PONATINIB"	"4"	"532.57"	"1"	"4.46"	"Ponatinib"	"Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12"	"Kd"	"'='"	"769.0"	"nM"	"6.11"	""	"Active"	"UO_0000065"	"11.48"	"0.21"	"1.65"	"9.30"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.92 None"
"CHEMBL2001019"	"PF-04217903"	"1"	"372.39"	"0"	"1.67"	"PF-04217903"	"OCCn1cc(-c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1614725"	"TAK-285"	"1"	"547.97"	"2"	"5.92"	"TAK-285"	"CC(C)(O)CC(=O)NCCn1ccc2ncnc(Nc3ccc(Oc4cccc(C(F)(F)F)c4)c(Cl)c3)c21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL119385"	"NEFLAMAPIMOD"	"2"	"436.27"	"1"	"5.49"	"3, VX-745"	"O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL124660"	"TANDUTINIB"	"2"	"562.72"	"2"	"5.03"	"Tandutinib"	"COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1421"	"DASATINIB"	"4"	"488.02"	"0"	"3.31"	"Dasatinib"	"Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1"	"Kd"	"'='"	"2122.0"	"nM"	"5.67"	""	"Active"	"UO_0000065"	"11.63"	"0.23"	"2.36"	"5.33"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.88 None"
"CHEMBL3991927"	""	"0"	"424.48"	"0"	"3.24"	"HMN-214"	"COc1ccc(S(=O)(=O)N(C(C)=O)c2ccccc2/C=C/c2cc[n+]([O-])cc2)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3353410"	"OSIMERTINIB"	"4"	"499.62"	"0"	"4.51"	"Osimertinib"	"C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2403108"	"CERITINIB"	"4"	"558.15"	"2"	"6.36"	"Ceritinib"	"Cc1cc(Nc2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)c(OC(C)C)cc1C1CCNCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL494089"	"GSK-690693"	"1"	"425.49"	"0"	"1.58"	"GSK-690693"	"CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2041933"	"AZD-7762"	"1"	"362.43"	"0"	"2.53"	"AZD-7762"	"NC(=O)Nc1cc(-c2cccc(F)c2)sc1C(=O)N[C@H]1CCCNC1"	"Kd"	"'='"	"83.0"	"nM"	"7.08"	""	"Uncertain"	"UO_0000065"	"19.54"	"0.39"	"4.55"	"7.36"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.74 None"
"CHEMBL1976040"	"ADAVOSERTIB"	"2"	"500.61"	"1"	"2.89"	"MK-1775"	"C=CCn1c(=O)c2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc2n1-c1cccc(C(C)(C)O)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL574738"	"AST-487"	"1"	"529.57"	"2"	"5.11"	"AST-487"	"CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1"	"Kd"	"'='"	"210.0"	"nM"	"6.68"	""	""	"UO_0000065"	"12.61"	"0.24"	"1.57"	"7.06"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL386051"	""	"0"	"443.36"	"1"	"5.77"	"PD-173955"	"CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1"	"Kd"	"'='"	"210.0"	"nM"	"6.68"	""	""	"UO_0000065"	"15.06"	"0.31"	"0.91"	"11.16"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1908395"	""	"0"	"497.04"	"0"	"3.76"	"JNJ-28312141"	"CN(C)CC(=O)N1CCC(c2ccc(NC(=O)c3nc(C#N)c[nH]3)c(C3=CCCCC3)c2)CC1.Cl"	"Kd"	"'='"	"370.0"	"nM"	"6.43"	""	""	"UO_0000065"	"13.96"	"0.26"	"2.67"	"6.12"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL388978"	"STAUROSPORINE"	"0"	"466.54"	"0"	"4.35"	"Staurosporine"	"CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"4.3"	"nM"	"8.37"	""	""	"UO_0000065"	"17.93"	"0.33"	"4.02"	"12.05"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL554"	"LAPATINIB"	"4"	"581.07"	"2"	"6.14"	"Lapatinib"	"CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL223360"	"LINIFANIB"	"3"	"375.41"	"0"	"4.90"	"ABT-869"	"Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cccc4[nH]nc(N)c34)cc2)c1"	"Kd"	"'='"	"830.0"	"nM"	"6.08"	""	""	"UO_0000065"	"16.20"	"0.30"	"1.18"	"6.35"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL105442"	"CI-1040"	"2"	"478.66"	"1"	"5.04"	"CI-1040"	"O=C(NOCC1CC1)c1ccc(F)c(F)c1Nc1ccc(I)cc1Cl"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL215152"	"AZD-1152-HQPA"	"0"	"507.57"	"1"	"3.50"	"AZD-1152 HQPA"	"CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL300138"	"ENZASTAURIN"	"3"	"515.62"	"1"	"4.93"	"LY-317615"	"Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21"	"Kd"	"'='"	"1800.0"	"nM"	"5.75"	""	""	"UO_0000065"	"11.14"	"0.20"	"0.81"	"7.96"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL103667"	"DORAMAPIMOD"	"2"	"527.67"	"2"	"5.99"	"BIRB-796"	"Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL576982"	"QUIZARTINIB"	"3"	"560.68"	"2"	"5.86"	"AC220"	"CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1241674"	""	"0"	"308.35"	"0"	"2.84"	"PP-242"	"CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c2c(N)ncnc21"	"Kd"	"'='"	"2100.0"	"nM"	"5.68"	""	""	"UO_0000065"	"18.41"	"0.34"	"2.84"	"5.37"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL221959"	"TOFACITINIB"	"4"	"312.38"	"0"	"1.54"	"CP-690550"	"C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1287853"	"FEDRATINIB"	"4"	"524.69"	"1"	"4.82"	"TG-101348"	"Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(S(=O)(=O)NC(C)(C)C)c1"	"Kd"	"'='"	"1300.0"	"nM"	"5.89"	""	""	"UO_0000065"	"11.22"	"0.22"	"1.07"	"5.43"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL464552"	""	"0"	"532.58"	"1"	"3.40"	"GSK-1838705A"	"CNC(=O)c1c(F)cccc1Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2[nH]ccc12"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL445813"	"AT-7519"	"2"	"382.25"	"0"	"2.45"	"AT-7519"	"O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL601719"	"CRIZOTINIB"	"4"	"450.35"	"1"	"5.04"	"Crizotinib"	"C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl"	"Kd"	"'='"	"39.0"	"nM"	"7.41"	""	""	"UO_0000065"	"16.45"	"0.34"	"2.37"	"9.50"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL939"	"GEFITINIB"	"4"	"446.91"	"0"	"4.28"	"Gefitinib"	"COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL1721885"	"SU-014813"	"2"	"442.49"	"0"	"1.69"	"SU-14813"	"Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1"	"Kd"	"'='"	"15.0"	"nM"	"7.82"	""	""	"UO_0000065"	"17.68"	"0.33"	"6.13"	"7.33"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL255863"	"NILOTINIB"	"4"	"529.53"	"2"	"6.36"	"Nilotinib"	"Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1"	"Kd"	"'='"	"890.0"	"nM"	"6.05"	""	""	"UO_0000065"	"11.43"	"0.21"	"-0.31"	"6.20"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL31965"	"CANERTINIB"	"3"	"485.95"	"0"	"4.39"	"CI-1033"	"C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL119385"	"NEFLAMAPIMOD"	"2"	"436.27"	"1"	"5.49"	"VX-745"	"O=c1ncn2nc(Sc3ccc(F)cc3F)ccc2c1-c1c(Cl)cccc1Cl"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL259084"	"MLN-8054"	"1"	"476.87"	"1"	"5.87"	"MLN-8054"	"O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL603469"	"LESTAURTINIB"	"3"	"439.47"	"0"	"3.47"	"CEP-701"	"C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O"	"Kd"	"'='"	"38.0"	"nM"	"7.42"	""	""	"UO_0000065"	"16.88"	"0.31"	"3.95"	"8.37"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL608154"	""	"0"	"366.81"	"0"	"4.33"	"MLN-120B"	"COc1c(Cl)cc2c([nH]c3cnccc32)c1NC(=O)c1cccnc1C"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL296468"	"BMS-387032"	"1"	"380.54"	"0"	"3.66"	"BMS-387032/SNS-032"	"CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL573339"	"PI-103"	"0"	"348.36"	"0"	"2.98"	"PI-103"	"Oc1cccc(-c2nc(N3CCOCC3)c3oc4ncccc4c3n2)c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL491473"	"CEDIRANIB"	"3"	"450.51"	"1"	"5.22"	"AZD-2171"	"COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1"	"Kd"	"'='"	"920.0"	"nM"	"6.04"	""	""	"UO_0000065"	"13.40"	"0.25"	"0.82"	"8.33"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL513909"	"BI-2536"	"2"	"521.67"	"1"	"3.56"	"BI-2536"	"CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)NC4CCN(C)CC4)cc3OC)nc2N1C1CCCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL608533"	"MIDOSTAURIN"	"4"	"570.65"	"2"	"5.91"	"PKC-412"	"CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"2100.0"	"nM"	"5.68"	""	""	"UO_0000065"	"9.95"	"0.18"	"-0.23"	"7.30"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL249697"	"BMS-345541"	"0"	"255.32"	"0"	"1.87"	"BMS-345541"	"Cc1ccc2nc(NCCN)c3ncc(C)n3c2c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1230020"	"PLX-4720"	"0"	"413.83"	"0"	"3.88"	"PLX-4720"	"CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Cl)cc23)c1F"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL553"	"ERLOTINIB"	"4"	"393.44"	"0"	"3.41"	"Erlotinib"	"C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1236107"	"SGX-523"	"1"	"359.42"	"0"	"3.22"	"SGX-523"	"Cn1cc(-c2ccc3nnc(Sc4ccc5ncccc5c4)n3n2)cn1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL4576489"	""	"0"	"915.85"	"None"	"None"	"8b"	"CO[C@@H]1[C@H](N(C)CCOCCOCCOCCNC(=O)CCC2=[N+]3C(=Cc4c(C)cc(C)n4[B-]3(F)F)C=C2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"24.0"	"nM"	"7.62"	""	""	"UO_0000065"	"8.32"	"None"	"None"	"None"	"False"	"CHEMBL4322789"	"Binding affinity to recombinant N-terminal His-FLAG-GST-tagged MAP4K1 (unknown origin) (1 to 346 residues) expressed in baculovirus infected Sf9 insect cells incubated for 1 hr by TR-FRET assay"	"B"	"BAO_0000219"	"cell-based format"	"Homo sapiens"	"None"	"None"	"Sf9"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL4321812"	"1"	"Scientific Literature"	"Bioorg Med Chem Lett"	"2019"	"CHEMBL3308860"	""
"CHEMBL554"	"LAPATINIB"	"4"	"581.07"	"2"	"6.14"	"Lapatinib"	"CS(=O)(=O)CCNCc1ccc(-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2)o1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL101253"	"VATALANIB"	"3"	"346.82"	"1"	"5.01"	"PTK-787"	"Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL278041"	"SB-202190"	"0"	"331.35"	"0"	"4.65"	"SB-202190"	"Oc1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL388978"	"STAUROSPORINE"	"0"	"466.54"	"0"	"4.35"	"Staurosporine"	"CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"4.3"	"nM"	"8.37"	""	""	"UO_0000065"	"17.93"	"0.33"	"4.02"	"12.05"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL574738"	"AST-487"	"1"	"529.57"	"2"	"5.11"	"AST-487"	"CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1"	"Kd"	"'='"	"210.0"	"nM"	"6.68"	""	""	"UO_0000065"	"12.61"	"0.24"	"1.57"	"7.06"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL221959"	"TOFACITINIB"	"4"	"312.38"	"0"	"1.54"	"CP-690550"	"C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL191003"	"JNJ-7706621"	"0"	"394.36"	"0"	"1.22"	"JNJ-7706621"	"Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=O)c1c(F)cccc1F"	"Kd"	"'='"	"120.0"	"nM"	"6.92"	""	""	"UO_0000065"	"17.55"	"0.35"	"5.70"	"4.74"	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL14762"	"SELICICLIB"	"2"	"354.46"	"0"	"3.20"	"Roscovitine/CYC-202"	"CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL1336"	"SORAFENIB"	"4"	"464.83"	"1"	"5.55"	"Sorafenib"	"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL288441"	"BOSUTINIB"	"4"	"530.46"	"2"	"5.19"	"SKI-606"	"COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl"	"Kd"	"'='"	"15.0"	"nM"	"7.82"	""	""	"UO_0000065"	"14.75"	"0.30"	"2.63"	"9.44"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1908397"	"KW-2449"	"1"	"332.41"	"0"	"2.78"	"KW-2449"	"O=C(c1ccc(/C=C/c2n[nH]c3ccccc23)cc1)N1CCNCC1"	"Kd"	"'='"	"63.0"	"nM"	"7.20"	""	""	"UO_0000065"	"21.66"	"0.39"	"4.42"	"11.80"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL450786"	"PHA-665752"	"0"	"641.62"	"2"	"6.11"	"PHA-665752"	"Cc1[nH]c(/C=C2\C(=O)Nc3ccc(S(=O)(=O)Cc4c(Cl)cccc4Cl)cc32)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1"	"Kd"	"'='"	"150.0"	"nM"	"6.82"	""	""	"UO_0000065"	"10.64"	"0.22"	"0.71"	"6.65"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL608533"	"MIDOSTAURIN"	"4"	"570.65"	"2"	"5.91"	"PKC-412"	"CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"2100.0"	"nM"	"5.68"	""	""	"UO_0000065"	"9.95"	"0.18"	"-0.23"	"7.30"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL535"	"SUNITINIB"	"4"	"398.48"	"0"	"3.33"	"Sunitinib"	"CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C"	"Kd"	"'='"	"16.0"	"nM"	"7.80"	""	""	"UO_0000065"	"19.56"	"0.37"	"4.47"	"10.09"	"True"	"CHEMBL1061176"	"Binding constant for MAP4K1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"Homo sapiens"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1150977"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2008"	"None"	""
"CHEMBL124660"	"TANDUTINIB"	"2"	"562.72"	"2"	"5.03"	"MLN-518"	"COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"True"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL1908394"	"GSK-461364"	"1"	"543.62"	"2"	"5.09"	"GSK-461364A"	"C[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1336"	"SORAFENIB"	"4"	"464.83"	"1"	"5.55"	"Sorafenib"	"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL1240703"	"CGP-52421"	"0"	"586.65"	"2"	"5.40"	"CGP-52421"	"CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)N[C@H]4O"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1244866"	"Binding affinity to HPK1"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1240346"	"1"	"Scientific Literature"	"Blood"	"2009"	"None"	""
"CHEMBL1908396"	""	"0"	"480.55"	"1"	"5.39"	"Ki-20227"	"COc1cc(Oc2ccnc3cc(OC)c(OC)cc23)ccc1NC(=O)NC(C)c1nccs1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL572881"	"MOTESANIB"	"3"	"373.46"	"0"	"4.04"	"AMG-706"	"CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc21"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1421"	"DASATINIB"	"4"	"488.02"	"0"	"3.31"	"Dasatinib"	"Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1"	"Kd"	"'='"	"980.0"	"nM"	"6.01"	""	""	"UO_0000065"	"12.31"	"0.25"	"2.70"	"5.64"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL502835"	"NINTEDANIB"	"4"	"539.64"	"1"	"3.62"	"BIBF-1120"	"COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1"	"Kd"	"'='"	"35.0"	"nM"	"7.46"	""	""	"UO_0000065"	"13.82"	"0.25"	"3.84"	"7.91"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL10"	"SB-203580"	"0"	"377.44"	"0"	"4.68"	"SB-203580"	"C[S+]([O-])c1ccc(-c2nc(-c3ccc(F)cc3)c(-c3ccncc3)[nH]2)cc1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL558752"	"RAF-265"	"2"	"518.42"	"2"	"6.93"	"CHIR-265/RAF-265"	"Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1289494"	"TIVOZANIB"	"4"	"454.87"	"1"	"5.64"	"Tivozanib"	"COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3544932"	"TAK-901"	"1"	"504.66"	"1"	"4.62"	"TAK-901"	"CCS(=O)(=O)c1cccc(-c2cc(C(=O)NC3CCN(C)CC3)c(C)c3[nH]c4ncc(C)cc4c23)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2048872"	""	"0"	"379.49"	"0"	"3.61"	"AZD-1208"	"N[C@@H]1CCCN(c2c(/C=C3\SC(=O)NC3=O)cccc2-c2ccccc2)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545083"	"RGB-286638"	"1"	"545.64"	"1"	"2.42"	"RGB-286638"	"COCCN1CCN(Cc2ccc(-c3n[nH]c4c3C(=O)c3c(NC(=O)NN5CCOCC5)cccc3-4)cc2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1233528"	"VOLASERTIB"	"3"	"618.83"	"1"	"4.27"	"Volasertib"	"CC[C@@H]1C(=O)N(C)c2cnc(Nc3ccc(C(=O)N[C@H]4CC[C@H](N5CCN(CC6CC6)CC5)CC4)cc3OC)nc2N1C(C)C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3991932"	"PEXMETINIB"	"1"	"556.64"	"2"	"6.07"	"Pexmetinib"	"Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)NCc2cc(F)ccc2Oc2ccc3c(cnn3CCO)c2)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1615025"	"TAK-733"	"1"	"504.23"	"1"	"1.07"	"TAK-733"	"Cn1c(=O)c(F)c(Nc2ccc(I)cc2F)c2c(=O)n(C[C@@H](O)CO)cnc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1229517"	"VEMURAFENIB"	"4"	"489.93"	"1"	"5.54"	"Vemurafenib"	"CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3184679"	"AZD-4547"	"2"	"463.58"	"0"	"3.65"	"AZD-4547"	"COc1cc(CCc2cc(NC(=O)c3ccc(N4CC(C)NC(C)C4)cc3)n[nH]2)cc(OC)c1"	"Kd"	"'='"	"354.0"	"nM"	"6.45"	""	"Active"	"UO_0000065"	"13.92"	"0.26"	"2.80"	"7.05"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.94 None"
"CHEMBL274654"	"ORANTINIB"	"3"	"310.35"	"0"	"3.14"	"Orantinib"	"Cc1[nH]c(/C=C2\C(=O)Nc3ccccc32)c(C)c1CCC(=O)O"	"Kd"	"'='"	"2015.0"	"nM"	"5.70"	""	"Active"	"UO_0000065"	"18.35"	"0.34"	"2.56"	"6.93"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.87 None"
"CHEMBL3544944"	"BMS-863233"	"2"	"289.72"	"0"	"2.75"	"XL-413"	"O=c1[nH]c(C2CCCN2)nc2c1oc1ccc(Cl)cc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1084546"	"PF-00562271"	"1"	"507.50"	"1"	"3.14"	"PF-562271"	"CN(c1ncccc1CNc1nc(Nc2ccc3c(c2)CC(=O)N3)ncc1C(F)(F)F)S(C)(=O)=O"	"Kd"	"'='"	"3984.0"	"nM"	"5.40"	""	"Active"	"UO_0000065"	"10.64"	"0.21"	"2.26"	"4.18"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.82 None"
"CHEMBL3348923"	"MLN-2480"	"1"	"506.30"	"1"	"3.98"	"MLN-2480"	"C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL494089"	"GSK-690693"	"1"	"425.49"	"0"	"1.58"	"GSK-690693"	"CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL384304"	"RG-547"	"2"	"441.46"	"0"	"1.41"	"R547"	"COc1ccc(F)c(F)c1C(=O)c1cnc(NC2CCN(S(C)(=O)=O)CC2)nc1N"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL31965"	"CANERTINIB"	"3"	"485.95"	"0"	"4.39"	"CI-1033"	"C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OCCCN1CCOCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL475251"	"R-406"	"2"	"470.46"	"0"	"3.63"	"R406"	"COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)NC(=O)C(C)(C)O4)n2)cc(OC)c1OC"	"Kd"	"'='"	"1400.0"	"nM"	"5.85"	""	""	"UO_0000065"	"12.44"	"0.24"	"2.22"	"4.55"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL124660"	"TANDUTINIB"	"2"	"562.72"	"2"	"5.03"	"MLN-518"	"COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1230609"	"FORETINIB"	"2"	"632.66"	"2"	"5.77"	"EXEL-2880/GSK-1363089"	"COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1"	"Kd"	"'='"	"44.0"	"nM"	"7.36"	""	""	"UO_0000065"	"11.63"	"0.22"	"1.59"	"6.61"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL536151"	""	"0"	"383.68"	"1"	"5.34"	"IMD-0354"	"O=C(Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(Cl)ccc1O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2107832"	"PIMASERTIB"	"2"	"431.21"	"0"	"1.65"	"Pimasertib"	"O=C(NC[C@H](O)CO)c1ccncc1Nc1ccc(I)cc1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL372764"	"PERIFOSINE"	"3"	"461.67"	"1"	"6.99"	"Perifosine"	"CCCCCCCCCCCCCCCCCCOP(=O)([O-])OC1CC[N+](C)(C)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL483321"	"CP-724714"	"2"	"469.55"	"0"	"4.95"	"CP-724714"	"COCC(=O)NC/C=C/c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1230165"	"SILMITASERTIB"	"2"	"349.78"	"0"	"4.88"	"Silmitasertib"	"O=C(O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL38380"	"FASUDIL"	"3"	"291.38"	"0"	"1.22"	"Fasudil"	"O=S(=O)(c1cccc2cnccc12)N1CCCNCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1801204"	"AZD-8055"	"1"	"465.55"	"0"	"2.64"	"AZD-8055"	"COc1ccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)cc1CO"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL608533"	"MIDOSTAURIN"	"4"	"570.65"	"2"	"5.91"	"Midostaurin"	"CO[C@@H]1[C@H](N(C)C(=O)c2ccccc2)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1944698"	"ZOTIRACICLIB"	"1"	"372.47"	"0"	"4.66"	"SB-1317"	"CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL215152"	"AZD-1152-HQPA"	"0"	"507.57"	"1"	"3.50"	"Barasertib_HQPA"	"CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545076"	"LY-2584702"	"1"	"445.42"	"0"	"4.30"	"LY-2584702"	"Cn1cc(-c2ccc(F)c(C(F)(F)F)c2)nc1C1CCN(c2ncnc3[nH]ncc23)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1738757"	"REBASTINIB"	"2"	"553.60"	"2"	"6.05"	"Rebastinib"	"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3cc(C(C)(C)C)nn3-c3ccc4ncccc4c3)c(F)c2)ccn1"	"Kd"	"'='"	"566.0"	"nM"	"6.25"	""	"Active"	"UO_0000065"	"11.28"	"0.21"	"0.20"	"5.08"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.96 None"
"CHEMBL3188267"	"CAPMATINIB"	"4"	"412.43"	"0"	"3.43"	"Capmatinib"	"CNC(=O)c1ccc(-c2cnc3ncc(Cc4ccc5ncccc5c4)n3n2)cc1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1236107"	"SGX-523"	"1"	"359.42"	"0"	"3.22"	"SGX-523"	"Cn1cc(-c2ccc3nnc(Sc4ccc5ncccc5c4)n3n2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1822792"	"MK-2461"	"2"	"495.56"	"0"	"2.15"	"MK-2461"	"CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(-c4cnn(C)c4)cc3c(=O)c2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL592445"	"GEDATOLISIB"	"2"	"615.74"	"1"	"3.02"	"Gedatolisib"	"CN(C)C1CCN(C(=O)c2ccc(NC(=O)Nc3ccc(-c4nc(N5CCOCC5)nc(N5CCOCC5)n4)cc3)cc2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL496102"	"AMG-208"	"2"	"383.41"	"0"	"3.93"	"AMG-208"	"COc1ccc2c(OCc3nnc4ccc(-c5ccccc5)nn34)ccnc2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL483158"	"ALISERTIB"	"3"	"518.93"	"2"	"5.75"	"Alisertib"	"COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL189963"	"PALBOCICLIB"	"4"	"447.54"	"0"	"2.97"	"Palbociclib"	"CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCNCC4)cn3)nc2n(C2CCCC2)c1=O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL402548"	"DANUSERTIB"	"2"	"474.57"	"0"	"2.64"	"Danusertib"	"CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(N4CCN(C)CC4)cc3)c2C1)c1ccccc1"	"Kd"	"'='"	"196.0"	"nM"	"6.71"	""	"Active"	"UO_0000065"	"14.13"	"0.26"	"4.07"	"7.15"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.91 None"
"CHEMBL2017974"	"BUPARLISIB"	"3"	"410.40"	"0"	"1.81"	"Buparlisib"	"Nc1cc(C(F)(F)F)c(-c2cc(N3CCOCC3)nc(N3CCOCC3)n2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1088751"	"PH-797804"	"2"	"477.31"	"0"	"4.43"	"PH-797804"	"CNC(=O)c1ccc(C)c(-n2c(C)cc(OCc3ccc(F)cc3F)c(Br)c2=O)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL575448"	"BMS-754807"	"2"	"461.51"	"0"	"3.61"	"BMS-754807"	"C[C@@]1(C(=O)Nc2ccc(F)nc2)CCCN1c1nc(Nc2cc(C3CC3)n[nH]2)c2cccn2n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL482767"	"SNS-314"	"1"	"430.95"	"0"	"4.52"	"SNS-314"	"O=C(Nc1cccc(Cl)c1)Nc1ncc(CCN=c2[nH]cnc3ccsc23)s1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2029988"	"CEP-32496"	"1"	"517.46"	"2"	"5.91"	"CEP-32496"	"COc1cc2ncnc(Oc3cccc(NC(=O)Nc4cc(C(C)(C)C(F)(F)F)on4)c3)c2cc1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1336"	"SORAFENIB"	"4"	"464.83"	"1"	"5.55"	"Sorafenib"	"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1645462"	"AC-480"	"1"	"530.56"	"1"	"3.86"	"AC-480"	"Cc1c(NC(=O)OC[C@@H]2COCCN2)cn2ncnc(Nc3ccc4c(cnn4Cc4cccc(F)c4)c3)c12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3301612"	"ENCORAFENIB"	"4"	"540.02"	"1"	"3.91"	"Encorafenib"	"COC(=O)N[C@@H](C)CNc1nccc(-c2cn(C(C)C)nc2-c2cc(Cl)cc(NS(C)(=O)=O)c2F)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL507361"	"MIRDAMETINIB"	"2"	"482.20"	"0"	"2.47"	"PD-325901"	"O=C(NOC[C@H](O)CO)c1ccc(F)c(F)c1Nc1ccc(I)cc1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1091644"	"LINSITINIB"	"3"	"421.50"	"0"	"4.82"	"Linsitinib"	"C[C@]1(O)C[C@@H](c2nc(-c3ccc4ccc(-c5ccccc5)nc4c3)c3c(N)nccn32)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2220486"	"LUCITANIB"	"2"	"443.50"	"0"	"4.42"	"Lucitanib"	"CNC(=O)c1cccc2cc(Oc3ccnc4cc(OCC5(N)CC5)c(OC)cc34)ccc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL413"	"SIROLIMUS"	"4"	"914.19"	"3"	"6.18"	"Rapamycin"	"CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1908391"	"MASITINIB"	"3"	"498.66"	"1"	"5.26"	"Masitinib"	"Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nc(-c2cccnc2)cs1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL400402"	""	"0"	"475.98"	"1"	"5.58"	"TG-100572"	"Cc1cc(-c2cc(O)ccc2Cl)cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL14762"	"SELICICLIB"	"2"	"354.46"	"0"	"3.20"	"Seliciclib"	"CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1094408"	"NMS-1286937"	"0"	"448.53"	"0"	"1.58"	"NMS-1286937"	"COc1ccc(N2CCN(C)CC2)cc1Nc1ncc2c(n1)-c1c(c(C(N)=O)nn1C)CC2"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2336325"	"VISTUSERTIB"	"2"	"462.55"	"0"	"2.50"	"AZD-2014"	"CNC(=O)c1cccc(-c2ccc3c(N4CCOC[C@@H]4C)nc(N4CCOC[C@@H]4C)nc3n2)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL296468"	"BMS-387032"	"1"	"380.54"	"0"	"3.66"	"BMS-387032"	"CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3544983"	"TESEVATINIB"	"3"	"491.39"	"1"	"5.79"	"Tesevatinib"	"COc1cc2c(Nc3ccc(Cl)c(Cl)c3F)ncnc2cc1OC[C@@H]1C[C@@H]2CN(C)C[C@@H]2C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2087361"	"ICOTINIB"	"3"	"391.43"	"0"	"3.16"	"Icotinib"	"C#Cc1cccc(Nc2ncnc3cc4c(cc23)OCCOCCOCCO4)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1236682"	"REFAMETINIB"	"2"	"572.34"	"1"	"3.48"	"Refametinib"	"COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1946170"	"REGORAFENIB"	"4"	"482.82"	"1"	"5.69"	"Regorafenib"	"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL603469"	"LESTAURTINIB"	"3"	"439.47"	"0"	"3.47"	"Lestaurtinib"	"C[C@]12O[C@H](C[C@]1(O)CO)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)CNC4=O"	"Kd"	"'='"	"252.0"	"nM"	"6.60"	""	"Active"	"UO_0000065"	"15.01"	"0.27"	"3.13"	"7.44"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.86 None"
"CHEMBL3544960"	"AT-13148"	"1"	"313.79"	"0"	"2.92"	"AT-13148"	"NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(-c2cn[nH]c2)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1614701"	"SELUMETINIB"	"4"	"457.69"	"0"	"3.53"	"Selumetinib"	"Cn1cnc2c(F)c(Nc3ccc(Br)cc3Cl)c(C(=O)NOCCO)cc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3039513"	"DECERNOTINIB"	"2"	"392.39"	"0"	"3.28"	"Decernotinib"	"CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1614713"	"CC-401"	"2"	"388.48"	"0"	"3.88"	"CC-401"	"c1cc(OCCN2CCCCC2)cc(-c2n[nH]c3ccc(-c4nnc[nH]4)cc23)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL576982"	"QUIZARTINIB"	"3"	"560.68"	"2"	"5.86"	"Quizartinib"	"CC(C)(C)c1cc(NC(=O)Nc2ccc(-c3cn4c(n3)sc3cc(OCCN5CCOCC5)ccc34)cc2)no1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL462018"	"TRICIRIBINE PHOSPHATE"	"2"	"400.29"	"1"	"-1.77"	"Triciribine"	"CN1N=C(N)c2cn([C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O)c3ncnc1c23"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1614766"	"RO-4987655"	"1"	"565.29"	"1"	"3.16"	"Ro-4987655"	"O=C(NOCCO)c1cc(CN2OCCCC2=O)c(F)c(F)c1Nc1ccc(I)cc1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2103842"	"VARLITINIB"	"2"	"466.95"	"1"	"5.25"	"Varlitinib"	"C[C@@H]1COC(Nc2ccc3ncnc(Nc4ccc(OCc5nccs5)c(Cl)c4)c3c2)=N1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3186534"	"RIVOCERANIB"	"3"	"397.48"	"0"	"4.68"	"Apatinib"	"N#CC1(c2ccc(NC(=O)c3cccnc3NCc3ccncc3)cc2)CCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2325741"	"CAPIVASERTIB"	"3"	"428.92"	"0"	"2.15"	"AZD-5363"	"NC1(C(=O)N[C@@H](CCO)c2ccc(Cl)cc2)CCN(c2ncnc3[nH]ccc23)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545328"	"XL-019"	"1"	"444.54"	"0"	"3.41"	"XL-019"	"O=C(Nc1ccc(-c2ccnc(Nc3ccc(N4CCOCC4)cc3)n2)cc1)C1CCCN1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1908394"	"GSK-461364"	"1"	"543.62"	"2"	"5.09"	"GSK-461364"	"C[C@@H](Oc1cc(-n2cnc3ccc(CN4CCN(C)CC4)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL411907"	"SONOLISIB"	"2"	"525.60"	"1"	"3.13"	"Sonolisib"	"C=CCN(/C=C1/C(=O)O[C@H](COC)[C@@]2(C)C1=C(O)C(=O)C1=C2[C@H](OC(C)=O)C[C@]2(C)C(=O)CC[C@@H]12)CC=C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1173655"	"AFATINIB"	"4"	"485.95"	"0"	"4.39"	"Afatinib"	"CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3991929"	"Cerdulatinib Hydrochloride"	"0"	"482.01"	"0"	"1.37"	"Cerdulatinib Hydrochloride"	"CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1.Cl"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL230011"	"TG100-115"	"2"	"346.35"	"0"	"2.33"	"TG-100115"	"Nc1nc(N)c2nc(-c3cccc(O)c3)c(-c3cccc(O)c3)nc2n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3039517"	"RABUSERTIB"	"2"	"436.31"	"0"	"2.87"	"Rabusertib"	"Cc1cnc(NC(=O)Nc2cc(Br)c(C)cc2OC[C@@H]2CNCCO2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1873475"	"IBRUTINIB"	"4"	"440.51"	"0"	"4.22"	"Ibrutinib"	"C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2180604"	"TAK-593"	"1"	"445.48"	"0"	"3.47"	"TAK-593"	"Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL521851"	"PICTILISIB"	"2"	"513.65"	"1"	"2.15"	"Pictilisib"	"CS(=O)(=O)N1CCN(Cc2cc3nc(-c4cccc5[nH]ncc45)nc(N4CCOCC4)c3s2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3301607"	"FILGOTINIB"	"4"	"425.51"	"0"	"1.98"	"Filgotinib"	"O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3188551"	"GSK-2636771"	"2"	"433.43"	"0"	"4.26"	"GSK-2636771"	"Cc1c(Cn2c(C)nc3c(C(=O)O)cc(N4CCOCC4)cc32)cccc1C(F)(F)F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3137331"	"DEFACTINIB"	"2"	"510.50"	"1"	"2.40"	"Defactinib"	"CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3nccnc3N(C)S(C)(=O)=O)n2)cc1"	"Kd"	"'='"	"3135.0"	"nM"	"5.50"	""	"Active"	"UO_0000065"	"10.78"	"0.21"	"3.10"	"3.87"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.8 None"
"CHEMBL2138625"	""	"0"	"507.01"	"1"	"4.67"	"AV-412"	"C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1C#CC(C)(C)N1CCN(C)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL415049"	"BARASERTIB"	"3"	"587.55"	"1"	"3.62"	"Barasertib"	"CCN(CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1)CCOP(=O)(O)O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3544966"	"GSK-1059615"	"1"	"333.37"	"0"	"3.62"	"GSK-1059615"	"O=C1NC(=O)/C(=C/c2ccc3nccc(-c4ccncc4)c3c2)S1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1236962"	"OMIPALISIB"	"1"	"505.51"	"1"	"4.84"	"Omipalisib"	"COc1ncc(-c2ccc3nccc(-c4ccnnc4)c3c2)cc1NS(=O)(=O)c1ccc(F)cc1F"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1908360"	"EVEROLIMUS"	"4"	"958.24"	"3"	"6.20"	"Certican"	"CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](OCCO)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(\C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C/C=C/C=C/1C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2103851"	"AMUVATINIB"	"2"	"447.52"	"0"	"3.30"	"Amuvatinib"	"S=C(NCc1ccc2c(c1)OCO2)N1CCN(c2ncnc3c2oc2ccccc23)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2103830"	"FOSTAMATINIB"	"4"	"580.47"	"2"	"3.09"	"Fostamatinib"	"COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL482967"	"CYC-116"	"1"	"368.47"	"0"	"3.07"	"Cyc-116"	"Cc1nc(N)sc1-c1ccnc(Nc2ccc(N3CCOCC3)cc2)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL460702"	"BMS-777607"	"2"	"512.90"	"2"	"5.19"	"BMS-777607"	"CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL571948"	"Y-39983"	"1"	"280.33"	"0"	"2.83"	"Y-39983"	"C[C@@H](N)c1ccc(C(=O)Nc2ccnc3[nH]ccc23)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1289926"	"AXITINIB"	"4"	"386.48"	"0"	"4.64"	"Axitinib"	"CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL101253"	"VATALANIB"	"3"	"346.82"	"1"	"5.01"	"Vatalanib"	"Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL255863"	"NILOTINIB"	"4"	"529.53"	"2"	"6.36"	"Nilotinib"	"Cc1cn(-c2cc(NC(=O)c3ccc(C)c(Nc4nccc(-c5cccnc5)n4)c3)cc(C(F)(F)F)c2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL206834"	"BAFETINIB"	"2"	"576.63"	"2"	"5.39"	"Bafetinib"	"Cc1ccc(NC(=O)c2ccc(CN3CC[C@H](N(C)C)C3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cncnc2)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL558752"	"RAF-265"	"2"	"518.42"	"2"	"6.93"	"RAF-265"	"Cn1c(Nc2ccc(C(F)(F)F)cc2)nc2cc(Oc3ccnc(-c4ncc(C(F)(F)F)[nH]4)c3)ccc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL24828"	"VANDETANIB"	"4"	"475.36"	"1"	"5.00"	"Vandetanib"	"COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1"	"Kd"	"'='"	"5500.0"	"nM"	"5.26"	""	""	"UO_0000065"	"11.06"	"0.24"	"0.26"	"8.84"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1789941"	"RUXOLITINIB"	"4"	"306.37"	"0"	"3.47"	"INCB18424"	"N#CC[C@H](C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1721885"	"SU-014813"	"2"	"442.49"	"0"	"1.69"	"SU-14813"	"Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1"	"Kd"	"'='"	"15.0"	"nM"	"7.82"	""	""	"UO_0000065"	"17.68"	"0.33"	"6.13"	"7.33"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1336"	"SORAFENIB"	"4"	"464.83"	"1"	"5.55"	"Sorafenib"	"CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1"	"Kd"	"'='"	"4800.0"	"nM"	"5.32"	""	""	"UO_0000065"	"11.44"	"0.23"	"-0.23"	"5.76"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL24828"	"VANDETANIB"	"4"	"475.36"	"1"	"5.00"	"Vandetanib"	"COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545137"	"PF-00477736"	"1"	"419.49"	"0"	"1.99"	"PF-477736"	"Cn1cc(C2=Nc3cc(NC(=O)C(N)C4CCCCC4)cc4c3C2=CNNC4=O)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545308"	"ROCILETINIB"	"3"	"555.56"	"1"	"4.78"	"Rociletinib"	"C=CC(=O)Nc1cccc(Nc2nc(Nc3ccc(N4CCN(C(C)=O)CC4)cc3OC)ncc2C(F)(F)F)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2105728"	"CRENOLANIB"	"3"	"443.55"	"0"	"3.92"	"Crenolanib"	"CC1(COc2ccc3c(c2)ncn3-c2ccc3cccc(N4CCC(N)CC4)c3n2)COC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2103840"	"DINACICLIB"	"3"	"396.50"	"0"	"2.28"	"Dinaciclib"	"CCc1cnn2c(NCc3ccc[n+]([O-])c3)cc(N3CCCC[C@H]3CCO)nc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL445813"	"AT-7519"	"2"	"382.25"	"0"	"2.45"	"AT-7519"	"O=C(NC1CCNCC1)c1n[nH]cc1NC(=O)c1c(Cl)cccc1Cl"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3218578"	"BGT-226"	"2"	"534.54"	"1"	"4.38"	"BGT-226"	"COc1ccc(-c2ccc3ncc4c(c3c2)n(-c2ccc(N3CCNCC3)c(C(F)(F)F)c2)c(=O)n4C)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2140408"	"AMG-900"	"1"	"503.59"	"2"	"6.64"	"AMG-900"	"Cc1csc(-c2nnc(Nc3ccc(Oc4ncccc4-c4ccnc(N)n4)cc3)c3ccccc23)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1983111"	""	"0"	"474.49"	"0"	"4.06"	"PF-03814735"	"CC(=O)NCC(=O)N1C2CCC1c1cc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)ccc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL221959"	"TOFACITINIB"	"4"	"312.38"	"0"	"1.54"	"Tofacitinib"	"C[C@@H]1CCN(C(=O)CC#N)C[C@@H]1N(C)c1ncnc2[nH]ccc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3813873"	"PEXIDARTINIB"	"4"	"417.82"	"1"	"5.23"	"Pexidartinib"	"FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL482968"	"ENMD-2076"	"2"	"375.48"	"0"	"3.17"	"ENMD-2076"	"Cc1cc(Nc2cc(N3CCN(C)CC3)nc(/C=C/c3ccccc3)n2)n[nH]1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL535"	"SUNITINIB"	"4"	"398.48"	"0"	"3.33"	"Sunitinib"	"CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C"	"Kd"	"'='"	"249.0"	"nM"	"6.60"	""	"Active"	"UO_0000065"	"16.57"	"0.31"	"3.27"	"8.55"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.96 None"
"CHEMBL2079588"	"TELATINIB"	"2"	"409.83"	"0"	"3.95"	"Telatinib"	"CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3182621"	"AZD-8330"	"1"	"461.23"	"0"	"1.83"	"AZD-8330"	"Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c1=O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545396"	"BMS-690514"	"2"	"368.44"	"0"	"1.38"	"BMS-690514"	"COc1cccc(Nc2ncnn3ccc(CN4CC[C@@H](N)[C@H](O)C4)c23)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL587723"	"AEE-788"	"2"	"440.60"	"0"	"4.94"	"AEE-788"	"CCN1CCN(Cc2ccc(-c3cc4c(N[C@H](C)c5ccccc5)ncnc4[nH]3)cc2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL180022"	"NERATINIB"	"4"	"557.05"	"2"	"5.93"	"HKI-272"	"CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C"	"Kd"	"'='"	"93.0"	"nM"	"7.03"	""	""	"UO_0000065"	"12.62"	"0.24"	"1.10"	"6.26"	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL1230607"	"PHA-793887"	"1"	"361.49"	"0"	"2.31"	"PHA-793887"	"CC(C)CC(=O)Nc1n[nH]c2c1CN(C(=O)C1CCN(C)CC1)C2(C)C"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL601719"	"CRIZOTINIB"	"4"	"450.35"	"1"	"5.04"	"Crizotinib"	"C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl"	"Kd"	"'='"	"1968.0"	"nM"	"5.71"	""	"Active"	"UO_0000065"	"12.67"	"0.26"	"0.67"	"7.32"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.97 None"
"CHEMBL598797"	"CUDC-101"	"1"	"434.50"	"0"	"4.20"	"CUDC-101"	"C#Cc1cccc(Nc2ncnc3cc(OC)c(OCCCCCCC(=O)NO)cc23)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2386889"	"SCH-900776"	"2"	"376.26"	"0"	"1.94"	"SCH-900776"	"Cn1cc(-c2cnn3c(N)c(Br)c([C@@H]4CCCNC4)nc23)cn1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3218576"	"COPANLISIB"	"4"	"480.53"	"1"	"0.66"	"Copanlisib"	"COc1c(OCCCN2CCOCC2)ccc2c1N=C(NC(=O)c1cnc(N)nc1)N1CCN=C21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL502835"	"NINTEDANIB"	"4"	"539.64"	"1"	"3.62"	"Nintedanib"	"COC(=O)c1ccc2c(c1)NC(=O)/C2=C(\Nc1ccc(N(C)C(=O)CN2CCN(C)CC2)cc1)c1ccccc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3187723"	"BINIMETINIB"	"4"	"441.23"	"0"	"3.01"	"Binimetinib"	"Cn1cnc2c(F)c(Nc3ccc(Br)cc3F)c(C(=O)NOCCO)cc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3991931"	""	"0"	"456.51"	"0"	"3.31"	"ONO-4059-analogue"	"C=CC(=O)N1CCC[C@H](n2c(=O)n(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545085"	"XL-228"	"1"	"437.55"	"0"	"3.30"	"XL-228"	"CC(C)c1cc(CNc2nc(Nc3cc(C4CC4)[nH]n3)cc(N3CCN(C)CC3)n2)on1"	"Kd"	"'='"	"15.0"	"nM"	"7.82"	""	"Active"	"UO_0000065"	"17.88"	"0.33"	"4.52"	"7.05"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.96 None"
"CHEMBL1614710"	"OSI-930"	"1"	"443.45"	"1"	"6.06"	"OSI-930"	"O=C(Nc1ccc(OC(F)(F)F)cc1)c1sccc1NCc1ccnc2ccccc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL270995"	"BRIVANIB ALANINATE"	"3"	"441.46"	"0"	"3.42"	"Brivanib_alaninate"	"Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)OC(=O)[C@H](C)N)c(C)c34)ccc2[nH]1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1233300"	"HYDROXYFASUDIL"	"0"	"307.38"	"0"	"0.92"	"Hydroxyfasudil"	"O=S(=O)(c1cccc2c(O)nccc12)N1CCCNCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3989868"	"TUCATINIB"	"4"	"480.53"	"1"	"5.09"	"ARRY-380"	"Cc1cc(Nc2ncnc3ccc(NC4=NC(C)(C)CO4)cc23)ccc1Oc1ccn2ncnc2c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL939"	"GEFITINIB"	"4"	"446.91"	"0"	"4.28"	"Gefitinib"	"COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL377300"	"BRIVANIB"	"3"	"370.38"	"0"	"3.52"	"BMS-540215"	"Cc1cc2c(F)c(Oc3ncnn4cc(OC[C@@H](C)O)c(C)c34)ccc2[nH]1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""
"CHEMBL3039525"	"GOLVATINIB"	"2"	"633.70"	"1"	"4.75"	"Golvatinib"	"CN1CCN(C2CCN(C(=O)Nc3cc(Oc4ccc(NC(=O)C5(C(=O)Nc6ccc(F)cc6)CC5)c(F)c4)ccn3)CC2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3301622"	"GILTERITINIB"	"4"	"552.72"	"1"	"2.70"	"Gilteritinib"	"CCc1nc(C(N)=O)c(Nc2ccc(N3CCC(N4CCN(C)CC4)CC3)c(OC)c2)nc1NC1CCOCC1"	"Kd"	"'='"	"108.0"	"nM"	"6.97"	""	"Uncertain"	"UO_0000065"	"12.60"	"0.24"	"4.27"	"5.75"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.99 None"
"CHEMBL572878"	"TOZASERTIB"	"2"	"464.60"	"0"	"3.50"	"Tozasertib"	"Cc1cc(Nc2cc(N3CCN(C)CC3)nc(Sc3ccc(NC(=O)C4CC4)cc3)n2)n[nH]1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL281948"	"K-252A"	"0"	"467.48"	"0"	"3.66"	"K-252a"	"COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4"	"Kd"	"'='"	"452.0"	"nM"	"6.34"	""	"Active"	"UO_0000065"	"13.57"	"0.25"	"2.68"	"6.70"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.99 None"
"CHEMBL283120"	"AXL-1717"	"2"	"414.41"	"0"	"2.41"	"AXL-1717"	"COc1cc([C@@H]2c3cc4c(cc3[C@H](O)[C@H]3COC(=O)[C@@H]23)OCO4)cc(OC)c1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1721885"	"SU-014813"	"2"	"442.49"	"0"	"1.69"	"SU-14813"	"Cc1[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1"	"Kd"	"'='"	"93.0"	"nM"	"7.03"	""	"Active"	"UO_0000065"	"15.89"	"0.30"	"5.34"	"6.59"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.95 None"
"CHEMBL1983268"	"ENTRECTINIB"	"4"	"560.65"	"2"	"5.03"	"Entrectinib"	"CN1CCN(c2ccc(C(=O)Nc3n[nH]c4ccc(Cc5cc(F)cc(F)c5)cc34)c(NC3CCOCC3)c2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL254760"	"MGCD-265"	"0"	"517.61"	"2"	"5.68"	"MGCD-265"	"Cn1cnc(-c2cc3nccc(Oc4ccc(NC(=S)NC(=O)Cc5ccccc5)cc4F)c3s2)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1738797"	"ALECTINIB"	"4"	"482.63"	"0"	"4.77"	"Alectinib"	"CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL91829"	"RUBOXISTAURIN"	"3"	"468.56"	"0"	"3.51"	"Ruboxistaurin"	"CN(C)C[C@@H]1CCn2cc(c3ccccc32)C2=C(C(=O)NC2=O)c2cn(c3ccccc23)CCO1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL300138"	"ENZASTAURIN"	"3"	"515.62"	"1"	"4.93"	"Enzastaurin"	"Cn1cc(C2=C(c3cn(C4CCN(Cc5ccccn5)CC4)c4ccccc34)C(=O)NC2=O)c2ccccc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545154"	"POZIOTINIB"	"2"	"491.35"	"1"	"5.38"	"Poziotinib"	"C=CC(=O)N1CCC(Oc2cc3c(Nc4ccc(Cl)c(Cl)c4F)ncnc3cc2OC)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3991934"	""	"0"	"591.54"	"1"	"4.90"	"ACTB-1003"	"COCc1c(-c2ccc(NC(=O)Nc3cc(C(F)(F)F)ccc3F)c(F)c2)c2c(N)ncnn2c1CN1CCOCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL491473"	"CEDIRANIB"	"3"	"450.51"	"1"	"5.22"	"Cediranib"	"COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545215"	"BMS-911543"	"2"	"432.53"	"0"	"3.50"	"BMS-911543"	"CCn1c(C(=O)N(C2CC2)C2CC2)cc2c3c(ncn3C)c(Nc3cc(C)n(C)n3)nc21"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL565612"	"SOTRASTAURIN"	"2"	"438.49"	"0"	"2.43"	"Sotrastaurin"	"CN1CCN(c2nc(C3=C(c4c[nH]c5ccccc45)C(=O)NC3=O)c3ccccc3n2)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL405130"	"WHI-P131"	"1"	"297.31"	"0"	"3.10"	"JANEX-1"	"COc1cc2ncnc(Nc3ccc(O)cc3)c2cc1OC"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2376648"	""	"0"	"547.42"	"1"	"4.28"	"X-396"	"C[C@@H](Oc1cc(C(=O)Nc2ccc(C(=O)N3CCN(C)CC3)cc2)nnc1N)c1c(Cl)ccc(F)c1Cl"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL259084"	"MLN-8054"	"1"	"476.87"	"1"	"5.87"	"MLN-8054"	"O=C(O)c1ccc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2F)=NC3)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL522892"	"DOVITINIB"	"3"	"392.44"	"0"	"2.54"	"Dovitinib"	"CN1CCN(c2ccc3nc(-c4c(N)c5c(F)cccc5[nH]c4=O)[nH]c3c2)CC1"	"Kd"	"'='"	"108.0"	"nM"	"6.97"	""	"Active"	"UO_0000065"	"17.75"	"0.33"	"4.43"	"7.41"	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	"r = 0.97 None"
"CHEMBL553"	"ERLOTINIB"	"4"	"393.44"	"0"	"3.41"	"Erlotinib"	"C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCOC)cc23)c1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2110732"	"DACOMITINIB"	"4"	"469.95"	"1"	"5.16"	"Dacomitinib"	"COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)/C=C/CN1CCCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL1667969"	"SAR-407899"	"2"	"244.29"	"0"	"1.66"	"SAR-407899"	"O=c1[nH]ccc2cc(OC3CCNCC3)ccc12"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2364611"	"GALUNISERTIB"	"2"	"369.43"	"0"	"3.51"	"Galunisertib"	"Cc1cccc(-c2nn3c(c2-c2ccnc4ccc(C(N)=O)cc24)CCC3)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL4084193"	""	"0"	"None"	"None"	"None"	"RDEA-436"	""	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL3545360"	"ASP-3026"	"1"	"580.76"	"2"	"3.77"	"ASP-3026"	"COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncnc(Nc2ccccc2S(=O)(=O)C(C)C)n1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL2408045"	"SAPITINIB"	"2"	"473.94"	"0"	"3.76"	"Sapitinib"	"CNC(=O)CN1CCC(Oc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)CC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL477772"	"PAZOPANIB"	"4"	"437.53"	"0"	"3.14"	"Pazopanib"	"Cc1ccc(Nc2nccc(N(C)c3ccc4c(C)n(C)nc4c3)n2)cc1S(N)(=O)=O"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL514201"	"TALMAPIMOD"	"2"	"513.01"	"1"	"3.98"	"Talmapimod"	"C[C@H]1CN(C(=O)c2cc3c(C(=O)C(=O)N(C)C)cn(C)c3cc2Cl)[C@H](C)CN1Cc1ccc(F)cc1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL253969"	"OSI-632"	"2"	"532.41"	"1"	"3.86"	"CP-547632"	"NC(=O)c1c(OCc2c(F)cc(Br)cc2F)nsc1NC(=O)NCCCCN1CCCC1"	"Kd"	"'>'"	"30000.0"	"nM"	""	""	"Inactive"	"UO_0000065"	""	""	""	""	"False"	"CHEMBL3991764"	"Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry."	"B"	"BAO_0000220"	"subcellular format"	"Homo sapiens"	"None"	"None"	"K-562, COLO 205, SK-N-BE(2) and MV-4-11"	"Cell lysate"	"Direct Binder: yes"	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL3991601"	"48"	"Kuster lab chemical proteomics drug profiling"	"Science"	"2017"	"None"	""
"CHEMBL941"	"IMATINIB"	"4"	"493.62"	"0"	"4.59"	"1"	"Cc1ccc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)cc1Nc1nccc(-c2cccnc2)n1"	"Kd"	"'>'"	"10000.0"	"nM"	""	""	""	"UO_0000065"	""	""	""	""	"False"	"CHEMBL1908513"	"Binding constant for HPK1 kinase domain"	"B"	"BAO_0000357"	"single protein format"	"None"	"None"	"None"	"None"	"None"	""	""	""	"CHEMBL5749"	"Mitogen-activated protein kinase kinase kinase kinase 1"	"Homo sapiens"	"SINGLE PROTEIN"	"CHEMBL1908390"	"1"	"Scientific Literature"	"Nat. Biotechnol."	"2011"	"None"	""